Times have changed dramatically, and Labour's recent battering came at the hands of the ascendant anti-immigrant Reform UK party on the right and, to a lesser-extent, the eco-populist Greens on the left. All the wards in the Makerfield constituency were won by Reform in the local races.
Reform's leader, Nigel Farage, said the party would "throw absolutely everything at it."
Despite those results, Burnham can capitalize on his reputation as someone who gets things done, said Tim Bale, a professor of politics at Queen Mary University of London.
"Andy Burnham is a big name in the northwest. There will be a lot of people who would like to see him get back into Parliament, not least to take down Keir Starmer," Bale said. "In some ways, it's a useful test for Burnham because if he can't beat Reform in that constituency, then quite frankly, he's not much use to the Labour Party as leader."
Labour has never ousted one of its leaders mid-term in government, but there is a process.