The latest reductions follow a round of job cuts in October, when Amazon said it was laying off 14,000 workers. While some Amazon units completed those "organizational changes" in October, others did not finish until now, Galetti said.
She said U.S.-based staff would be given 90 days to look for a new role internally. Those who are unsuccessful or don't want a new job will be offered severance pay, outplacement services and health insurance benefits, she said.
"While we're making these changes, we'll also continue hiring and investing in strategic areas and functions that are critical to our future," Galetti said.
CEO Andy Jassy, who has aggressively cut costs since succeeding founder Jeff Bezos in 2021, said in June that he anticipated generative AI would reduce Amazon's corporate workforce in the next few years.
The layoffs announced Wednesday are Amazon's biggest since 2023, when the company cut 27,000 jobs.