Amazon Cargo Plane Crashes at Miami Airport, Killing Five

At least five people have been killed and five others injured after an Amazon Prime Air cargo aircraft crashed while landing at Miami International Airport on Sunday, according to local officials.

Prime Air Flight 7598, a Boeing 767-300, overran the airport's diagonal runway shortly before 2pm EDT and struck several vehicles on the ground, officials said during an afternoon news conference.

Three of the five injured people were in critical condition, authorities said.

The crash prompted officials to shut down all runways and taxiways at Miami International Airport as emergency crews responded to the scene. The closures were expected to cause widespread disruption, with passengers warned to anticipate significant delays and possible flight cancellations.

US Transportation Secretary Sean Duffy urged travellers to prepare for disruption, saying the airport's operations had been severely affected by the incident.

Miami-Dade Fire Rescue reported that multiple patients were being treated following the crash.

The aircraft had flown from San Juan, Puerto Rico, before attempting to land in Miami, according to the Federal Aviation Administration.

Although the flight operated under the Amazon Prime Air name, the aircraft was operated by cargo carrier 21 Air on Amazon's behalf, an Amazon spokesperson confirmed.

Authorities continued to investigate the circumstances surrounding the crash, including what caused the aircraft to overrun the runway and collide with vehicles on the ground.

The incident caused significant disruption at one of the United States' busiest airports, with airport officials warning travellers that delays and cancellations were likely to continue while emergency operations and the initial investigation were underway.